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Correlation of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase with sensitivity of gastrointestinal cancer cells to 5-fluorouracil and 5-fluoro-2’-deoxyuridine

AIM: To determine the expression levels of three metabolic enzymes of fluoropyrimidines: thymidylate synthase (TS), thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) in seven human gastrointestinal cancer cell lines, and to compare the enzyme levels with the sensitivity to 5-flu...

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Bibliografski detalji
Izdano u:World J Gastroenterol
Glavni autori: Ma, Tao, Zhu, Zheng-Gang, Ji, Yu-Bao, Zhang, Yi, Yu, Ying-Yan, Liu, Bing-Ya, Yin, Hao-Ran, Lin, Yan-Zhen
Format: Artigo
Jezik:Inglês
Izdano: Baishideng Publishing Group Inc 2004
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716997/
https://ncbi.nlm.nih.gov/pubmed/14716816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v10.i2.172
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