Extended Safety, Immunogenicity and Efficacy of a Blood-Stage Malaria Vaccine in Malian Children: 24-Month Follow-Up of a Randomized, Double-Blinded Phase 2 Trial

BACKGROUND: The FMP2.1/AS02(A) candidate malaria vaccine was tested in a Phase 2 study in Mali. Based on results from the first eight months of follow-up, the vaccine appeared well-tolerated and immunogenic. It had no significant efficacy based on the primary endpoint, clinical malaria, but marginal...

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Hlavní autoři: Laurens, Matthew B., Thera, Mahamadou A., Coulibaly, Drissa, Ouattara, Amed, Kone, Abdoulaye K., Guindo, Ando B., Traore, Karim, Traore, Idrissa, Kouriba, Bourema, Diallo, Dapa A., Diarra, Issa, Daou, Modibo, Dolo, Amagana, Tolo, Youssouf, Sissoko, Mahamadou S., Niangaly, Amadou, Sissoko, Mady, Takala-Harrison, Shannon, Lyke, Kirsten E., Wu, Yukun, Blackwelder, William C., Godeaux, Olivier, Vekemans, Johan, Dubois, Marie-Claude, Ballou, W. Ripley, Cohen, Joe, Dube, Tina, Soisson, Lorraine, Diggs, Carter L., House, Brent, Bennett, Jason W., Lanar, David E., Dutta, Sheetij, Heppner, D. Gray, Plowe, Christopher V., Doumbo, Ogobara K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832522/
https://ncbi.nlm.nih.gov/pubmed/24260195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079323
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