Safety and Immunogenicity of an AMA-1 Malaria Vaccine in Malian Adults: Results of a Phase 1 Randomized Controlled Trial

BACKGROUND: The objective was to evaluate the safety, reactogenicity and immunogenicity of the AMA-1-based blood-stage malaria vaccine FMP2.1/AS02A in adults exposed to seasonal malaria. METHODOLOGY/PRINCIPAL FINDINGS: A phase 1 double blind randomized controlled dose escalation trial was conducted...

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Detalhes bibliográficos
Main Authors: Thera, Mahamadou A., Doumbo, Ogobara K., Coulibaly, Drissa, Diallo, Dapa A., Kone, Abdoulaye K., Guindo, Ando B., Traore, Karim, Dicko, Alassane, Sagara, Issaka, Sissoko, Mahamadou S., Baby, Mounirou, Sissoko, Mady, Diarra, Issa, Niangaly, Amadou, Dolo, Amagana, Daou, Modibo, Diawara, Sory I., Heppner, D. Gray, Stewart, V. Ann, Angov, Evelina, Bergmann-Leitner, Elke S., Lanar, David E., Dutta, Sheetij, Soisson, Lorraine, Diggs, Carter L., Leach, Amanda, Owusu, Alex, Dubois, Marie-Claude, Cohen, Joe, Nixon, Jason N., Gregson, Aric, Takala, Shannon L., Lyke, Kirsten E., Plowe, Christopher V.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2186380/
https://ncbi.nlm.nih.gov/pubmed/18213374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001465
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