Safety and Immunogenicity of an AMA-1 Malaria Vaccine in Malian Adults: Results of a Phase 1 Randomized Controlled Trial

BACKGROUND: The objective was to evaluate the safety, reactogenicity and immunogenicity of the AMA-1-based blood-stage malaria vaccine FMP2.1/AS02A in adults exposed to seasonal malaria. METHODOLOGY/PRINCIPAL FINDINGS: A phase 1 double blind randomized controlled dose escalation trial was conducted...

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Main Authors: Thera, Mahamadou A., Doumbo, Ogobara K., Coulibaly, Drissa, Diallo, Dapa A., Kone, Abdoulaye K., Guindo, Ando B., Traore, Karim, Dicko, Alassane, Sagara, Issaka, Sissoko, Mahamadou S., Baby, Mounirou, Sissoko, Mady, Diarra, Issa, Niangaly, Amadou, Dolo, Amagana, Daou, Modibo, Diawara, Sory I., Heppner, D. Gray, Stewart, V. Ann, Angov, Evelina, Bergmann-Leitner, Elke S., Lanar, David E., Dutta, Sheetij, Soisson, Lorraine, Diggs, Carter L., Leach, Amanda, Owusu, Alex, Dubois, Marie-Claude, Cohen, Joe, Nixon, Jason N., Gregson, Aric, Takala, Shannon L., Lyke, Kirsten E., Plowe, Christopher V.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2008
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2186380/
https://ncbi.nlm.nih.gov/pubmed/18213374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001465
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