Safety and Immunogenicity of an AMA1 Malaria Vaccine in Malian Children: Results of a Phase 1 Randomized Controlled Trial

BACKGROUND: The objective was to evaluate the safety and immunogenicity of the AMA1-based malaria vaccine FMP2.1/AS02(A) in children exposed to seasonal falciparum malaria. METHODOLOGY/PRINCIPAL FINDINGS: A Phase 1 double blind randomized controlled dose escalation trial was conducted in Bandiagara,...

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Main Authors: Thera, Mahamadou A., Doumbo, Ogobara K., Coulibaly, Drissa, Laurens, Matthew B., Kone, Abdoulaye K., Guindo, Ando B., Traore, Karim, Sissoko, Mady, Diallo, Dapa A., Diarra, Issa, Kouriba, Bourema, Daou, Modibo, Dolo, Amagana, Baby, Mounirou, Sissoko, Mahamadou S., Sagara, Issaka, Niangaly, Amadou, Traore, Idrissa, Olotu, Ally, Godeaux, Olivier, Leach, Amanda, Dubois, Marie-Claude, Ballou, W. Ripley, Cohen, Joe, Thompson, Darby, Dube, Tina, Soisson, Lorraine, Diggs, Carter L., Takala, Shannon L., Lyke, Kirsten E., House, Brent, Lanar, David E., Dutta, Sheetij, Heppner, D. Gray, Plowe, Christopher V.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2816207/
https://ncbi.nlm.nih.gov/pubmed/20140214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009041
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