Safety and Immunogenicity of an AMA1 Malaria Vaccine in Malian Children: Results of a Phase 1 Randomized Controlled Trial

BACKGROUND: The objective was to evaluate the safety and immunogenicity of the AMA1-based malaria vaccine FMP2.1/AS02(A) in children exposed to seasonal falciparum malaria. METHODOLOGY/PRINCIPAL FINDINGS: A Phase 1 double blind randomized controlled dose escalation trial was conducted in Bandiagara,...

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Main Authors: Thera, Mahamadou A., Doumbo, Ogobara K., Coulibaly, Drissa, Laurens, Matthew B., Kone, Abdoulaye K., Guindo, Ando B., Traore, Karim, Sissoko, Mady, Diallo, Dapa A., Diarra, Issa, Kouriba, Bourema, Daou, Modibo, Dolo, Amagana, Baby, Mounirou, Sissoko, Mahamadou S., Sagara, Issaka, Niangaly, Amadou, Traore, Idrissa, Olotu, Ally, Godeaux, Olivier, Leach, Amanda, Dubois, Marie-Claude, Ballou, W. Ripley, Cohen, Joe, Thompson, Darby, Dube, Tina, Soisson, Lorraine, Diggs, Carter L., Takala, Shannon L., Lyke, Kirsten E., House, Brent, Lanar, David E., Dutta, Sheetij, Heppner, D. Gray, Plowe, Christopher V.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2816207/
https://ncbi.nlm.nih.gov/pubmed/20140214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009041
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