Conjunctive therapy of cisplatin with the OCT2 inhibitor cimetidine: influence on antitumor efficacy and systemic clearance

The organic cation transporter 2 (OCT2) regulates uptake of cisplatin in proximal tubules and inhibition of OCT2 protects against severe cisplatin-induced nephrotoxicity. However, it remains uncertain whether potent OCT2 inhibitors such as cimetidine can influence the antitumor properties and/or dis...

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Detalhes bibliográficos
Main Authors: Sprowl, JA, van Doorn, L, Hu, S, van Gerven, L, de Bruijn, P, Li, L, Gibson, AA, Mathijssen, RH, Sparreboom, A
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832209/
https://ncbi.nlm.nih.gov/pubmed/23863876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2013.145
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