Cisplatin-Induced Renal Injury is Independently Mediated by OCT2 and p53

PURPOSE: Tubular secretion of cisplatin is abolished in mice deficient for the organic cation transporters Oct1 and Oct2 [Oct1/2(−/−) mice], and these animals are protected from severe cisplatin-induced kidney damage. Since tubular necrosis is not completely absent in Oct1/2(−/−) mice, we hypothesiz...

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Autori principali: Sprowl, Sprowl, Lancaster, Cynthia S., Pabla, Navjotsingh, Hermann, Edwin, Kosloske, Ashley M., Gibson, Alice A., Li, Lie, Zeeh, Dorothea, Schlatter, Eberhard, Janke, Laura J., Ciarimboli, Giuliano, Sparreboom, Alex
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119572/
https://ncbi.nlm.nih.gov/pubmed/24916697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0319
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