Influence of Oct1/Oct2-Deficiency on Cisplatin-Induced Changes in Urinary N-Acetyl-β-D-Glucosaminidase

Organic cation transporters have previously been implicated in cisplatin nephrotoxicity. In this study, we found that renal tubular secretion of cisplatin is abolished in mice lacking the Oct1 and Oct2 transporters [Oct1/2(−/−) mice], and these mice are protected from experiencing severe cisplatin-i...

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Detalhes bibliográficos
Main Authors: Franke, Ryan M., Kosloske, Ashley M., Lancaster, Cynthia S., Filipski, Kelly K., Hu, Chaoxin, Zolk, Oliver, Mathijssen, Ron H., Sparreboom, Alex
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514415/
https://ncbi.nlm.nih.gov/pubmed/20601443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0949
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