Cisplatin-Induced Downregulation of OCTN2 Affects Carnitine (Vitamin B(T)) Wasting

PURPOSE: Carnitine is an essential cofactor for mitochondrial fatty acid oxidation that is actively reabsorbed by the luminal transporter Octn2 (Slc22a5). Since the nephrotoxic agent cisplatin causes urinary loss of carnitine in humans, we hypothesized that cisplatin may affect Octn2 function. EXPER...

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Detalhes bibliográficos
Main Authors: Lancaster, Cynthia S., Hu, Chaoxin, Franke, Ryan M., Filipski, Kelly K., Orwick, Shelley J., Chen, Zhaoyuan, Zuo, Zhili, Loos, Walter J., Sparreboom, Alex
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531239/
https://ncbi.nlm.nih.gov/pubmed/20858838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-1239
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