Cisplatin-Induced Downregulation of OCTN2 Affects Carnitine (Vitamin B(T)) Wasting

PURPOSE: Carnitine is an essential cofactor for mitochondrial fatty acid oxidation that is actively reabsorbed by the luminal transporter Octn2 (Slc22a5). Since the nephrotoxic agent cisplatin causes urinary loss of carnitine in humans, we hypothesized that cisplatin may affect Octn2 function. EXPER...

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Bibliografische gegevens
Hoofdauteurs: Lancaster, Cynthia S., Hu, Chaoxin, Franke, Ryan M., Filipski, Kelly K., Orwick, Shelley J., Chen, Zhaoyuan, Zuo, Zhili, Loos, Walter J., Sparreboom, Alex
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531239/
https://ncbi.nlm.nih.gov/pubmed/20858838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-1239
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