Cisplatin-Induced Downregulation of OCTN2 Affects Carnitine (Vitamin B(T)) Wasting

PURPOSE: Carnitine is an essential cofactor for mitochondrial fatty acid oxidation that is actively reabsorbed by the luminal transporter Octn2 (Slc22a5). Since the nephrotoxic agent cisplatin causes urinary loss of carnitine in humans, we hypothesized that cisplatin may affect Octn2 function. EXPER...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Lancaster, Cynthia S., Hu, Chaoxin, Franke, Ryan M., Filipski, Kelly K., Orwick, Shelley J., Chen, Zhaoyuan, Zuo, Zhili, Loos, Walter J., Sparreboom, Alex
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531239/
https://ncbi.nlm.nih.gov/pubmed/20858838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-1239
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires