Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions

Acute kidney injury (AKI) is a potentially fatal syndrome characterized by a rapid decline in kidney function caused by ischemic or toxic injury to renal tubular cells. The widely used chemotherapy drug cisplatin accumulates preferentially in the renal tubular cells and is a frequent cause of drug-i...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Pabla, Navjotsingh, Gibson, Alice A., Buege, Mike, Ong, Su Sien, Li, Lie, Hu, Shuiying, Du, Guoqing, Sprowl, Jason A., Vasilyeva, Aksana, Janke, Laura J., Schlatter, Eberhard, Chen, Taosheng, Ciarimboli, Giuliano, Sparreboom, Alex
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413320/
https://ncbi.nlm.nih.gov/pubmed/25848011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424313112
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