Kinetic analysis of cytokine-mediated receptor assembly using engineered FC heterodimers

A method for analyzing ligand–receptor binding kinetics is described, which is based on an engineered FC domain (FChk) that forms a covalent heterodimer. To validate the system, the type I IFN receptors (IFNAR1 and IFNAR2) were expressed as IFNAR1-FChk, IFNAR2-FCkh, and IFNAR1/IFNAR2-FChk fusion pro...

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Detaylı Bibliyografya
Asıl Yazarlar: Deshpande, Ashlesha, Putcha, Balananda-Dhurjati Kumar, Kuruganti, Srilalitha, Walter, Mark R
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Publishing Ltd 2013
Konular:
Methods and Applications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832046/
https://ncbi.nlm.nih.gov/pubmed/23703950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2285
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