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Direct Interdomain Interactions Can Mediate Allosterism in the Thyroid Receptor

The thyroid (TR) and retinoid X receptors (RXR) belong to the nuclear receptor (NR) superfamily of ligand-mediated transcription factors. At the molecular level, TR activity is specifically modulated by interactions with the ligand 3,3′,5 triiodo-l-thyronine (T3), RXR, DNA, and co-activators such as...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Putcha, Balananda-Dhurjati K., Fernandez, Elias J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755658/
https://ncbi.nlm.nih.gov/pubmed/19561066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.026682
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