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Remodeling of the interdomain allosteric linker upon membrane binding of CCTα pulls its active site close to the membrane surface
The rate-limiting step in the biosynthesis of the major membrane phospholipid, phosphatidylcholine, is catalyzed by CTP:phosphocholine cytidylyltransferase (CCT), which is regulated by reversible membrane binding of a long amphipathic helix (domain M). The M domain communicates with the catalytic do...
Tallennettuna:
| Julkaisussa: | J Biol Chem |
|---|---|
| Päätekijät: | , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Biochemistry and Molecular Biology
2019
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6802524/ https://ncbi.nlm.nih.gov/pubmed/31488548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009850 |
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