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Remodeling of the interdomain allosteric linker upon membrane binding of CCTα pulls its active site close to the membrane surface

The rate-limiting step in the biosynthesis of the major membrane phospholipid, phosphatidylcholine, is catalyzed by CTP:phosphocholine cytidylyltransferase (CCT), which is regulated by reversible membrane binding of a long amphipathic helix (domain M). The M domain communicates with the catalytic do...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Knowles, Daniel G., Lee, Jaeyong, Taneva, Svetla G., Cornell, Rosemary B.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802524/
https://ncbi.nlm.nih.gov/pubmed/31488548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009850
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