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Interdomain communication in the phosphatidylcholine regulatory enzyme, CCTα, relies on a modular αE helix
CTP:phosphocholine cytidylyltransferase (CCT), the rate-limiting enzyme in phosphatidylcholine (PC) synthesis, is an amphitropic enzyme that regulates PC homeostasis. Recent work has suggested that CCTα activation by binding to a PC-deficient membrane involves conformational transitions in a helix p...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6802526/ https://ncbi.nlm.nih.gov/pubmed/31488547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009849 |
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