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Interdomain communication in the phosphatidylcholine regulatory enzyme, CCTα, relies on a modular αE helix

CTP:phosphocholine cytidylyltransferase (CCT), the rate-limiting enzyme in phosphatidylcholine (PC) synthesis, is an amphitropic enzyme that regulates PC homeostasis. Recent work has suggested that CCTα activation by binding to a PC-deficient membrane involves conformational transitions in a helix p...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Taneva, Svetla G., Lee, Jaeyong, Knowles, Daniel G., Tishyadhigama, Chanajai, Chen, Hongwen, Cornell, Rosemary B.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802526/
https://ncbi.nlm.nih.gov/pubmed/31488547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009849
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