An interdomain helix in IRE1α mediates the conformational change required for the sensor's activation

The unfolded protein response plays an evolutionarily conserved role in homeostasis, and its dysregulation often leads to human disease, including diabetes and cancer. IRE1α is a major transducer that conveys endoplasmic reticulum stress via biochemical signals, yet major gaps persist in our underst...

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Publicado en:J Biol Chem
Autores principales: Ricci, Daniela, Tutton, Stephen, Marrocco, Ilaria, Ying, Mingjie, Blumenthal, Daniel, Eletto, Daniela, Vargas, Jade, Boyle, Sarah, Fazelinia, Hossein, Qian, Lei, Suresh, Krishna, Taylor, Deanne, Paton, James C., Paton, Adrienne W., Tang, Chih-Hang Anthony, Hu, Chih-Chi Andrew, Radhakrishnan, Ravi, Gidalevitz, Tali, Argon, Yair
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8203841/
https://ncbi.nlm.nih.gov/pubmed/34000298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100781
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