An interdomain helix in IRE1α mediates the conformational change required for the sensor's activation

The unfolded protein response plays an evolutionarily conserved role in homeostasis, and its dysregulation often leads to human disease, including diabetes and cancer. IRE1α is a major transducer that conveys endoplasmic reticulum stress via biochemical signals, yet major gaps persist in our underst...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ricci, Daniela, Tutton, Stephen, Marrocco, Ilaria, Ying, Mingjie, Blumenthal, Daniel, Eletto, Daniela, Vargas, Jade, Boyle, Sarah, Fazelinia, Hossein, Qian, Lei, Suresh, Krishna, Taylor, Deanne, Paton, James C., Paton, Adrienne W., Tang, Chih-Hang Anthony, Hu, Chih-Chi Andrew, Radhakrishnan, Ravi, Gidalevitz, Tali, Argon, Yair
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8203841/
https://ncbi.nlm.nih.gov/pubmed/34000298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100781
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados