An auto-inhibitory helix in CTP:phosphocholine cytidylyltransferase hijacks the catalytic residue and constrains a pliable, domain-bridging helix pair

The activity of CTP:phosphocholine cytidylyltransferase (CCT), a key enzyme in phosphatidylcholine synthesis, is regulated by reversible interactions of a lipid-inducible amphipathic helix (domain M) with membrane phospholipids. When dissociated from membranes, a portion of the M domain functions as...

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Vydáno v:J Biol Chem
Hlavní autoři: Ramezanpour, Mohsen, Lee, Jaeyong, Taneva, Svetla G., Tieleman, D. Peter, Cornell, Rosemary B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936808/
https://ncbi.nlm.nih.gov/pubmed/29519816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002053
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