C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice

Accumulating evidence from mice expressing ALS-causing mutations in superoxide dismutase (SOD1) has implicated pathological immune responses in motor neuron degeneration. This includes microglial activation, lymphocyte infiltration, and the induction of C1q, the initiating component of the classic c...

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Bibliographic Details
Main Authors: Lobsiger, Christian S., Boillée, Severine, Pozniak, Christine, Khan, Amir M., McAlonis-Downes, Melissa, Lewcock, Joseph W., Cleveland, Don W.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831990/
https://ncbi.nlm.nih.gov/pubmed/24170856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1318309110
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