Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice

Dominant mutations in ubiquitously expressed superoxide dismutase (SOD1) cause familial ALS by provoking premature death of adult motor neurons. To test whether mutant damage to cell types beyond motor neurons is required for the onset of motor neuron disease, we generated chimeric mice in which all...

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Autores principales: Yamanaka, Koji, Boillee, Severine, Roberts, Elizabeth A., Garcia, Michael L., McAlonis-Downes, Melissa, Mikse, Oliver R., Cleveland, Don W., Goldstein, Lawrence S. B.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2008
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396671/
https://ncbi.nlm.nih.gov/pubmed/18492803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802556105
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