Monoallelic loss of tumor suppressor GRIM-19 promotes tumorigenesis in mice

Gene-associated with retinoid-interferon induced mortality-19 (GRIM-19), a STAT3-inhibitory protein, was isolated as a growth-suppressive gene product using a genome-wide expression knockdown screen. We and others have shown a loss of expression and occurrence of mutations in the GRIM-19 gene in a v...

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Autori principali: Kalakonda, Sudhakar, Nallar, Shreeram C., Jaber, Sausan, Keay, Susan K., Rorke, Ellen, Munivenkatappa, Raghava, Lindner, Daniel J., Fiskum, Gary M., Kalvakolanu, Dhananjaya V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831468/
https://ncbi.nlm.nih.gov/pubmed/24145455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303760110
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