Identification of a Structural Motif in the Tumor-Suppressive Protein GRIM-19 Required for Its Antitumor Activity

We have previously isolated GRIM-19, a novel growth suppressor, using a genetic method. GRIM-19 ablates cell growth by inhibiting the transcription factor signal transducer and activator of transcription 3 (STAT3). Up-regulation of STAT3 and growth promotion were observed in a number of human tumors...

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Main Authors: Nallar, Shreeram C., Kalakonda, Sudhakar, Sun, Peng, Ohmori, Yoshihiro, Hiroi, Miki, Mori, Kazumasa, Lindner, Daniel J., Kalvakolanu, Dhananjaya V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913340/
https://ncbi.nlm.nih.gov/pubmed/20595633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.091280
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