Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

Mislocalization and aggregation of Aβ and Tau combined with loss of synapses and microtubules (MTs) are hallmarks of Alzheimer disease. We exposed mature primary neurons to Aβ oligomers and analysed changes in the Tau/MT system. MT breakdown occurs in dendrites invaded by Tau (Tau missorting) and is...

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Détails bibliographiques
Auteurs principaux: Zempel, Hans, Luedtke, Julia, Kumar, Yatender, Biernat, Jacek, Dawson, Hana, Mandelkow, Eckhard, Mandelkow, Eva-Maria
Format: Artigo
Langue:Inglês
Publié: European Molecular Biology Organization 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831312/
https://ncbi.nlm.nih.gov/pubmed/24065130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.207
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