Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

Mislocalization and aggregation of Aβ and Tau combined with loss of synapses and microtubules (MTs) are hallmarks of Alzheimer disease. We exposed mature primary neurons to Aβ oligomers and analysed changes in the Tau/MT system. MT breakdown occurs in dendrites invaded by Tau (Tau missorting) and is...

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Main Authors: Zempel, Hans, Luedtke, Julia, Kumar, Yatender, Biernat, Jacek, Dawson, Hana, Mandelkow, Eckhard, Mandelkow, Eva-Maria
Formato: Artigo
Idioma:Inglês
Publicado: European Molecular Biology Organization 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831312/
https://ncbi.nlm.nih.gov/pubmed/24065130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.207
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