Development and Implementation of a High-Throughput Compound Screening Assay for Targeting Disrupted ER Calcium Homeostasis in Alzheimer's Disease

Disrupted intracellular calcium homeostasis is believed to occur early in the cascade of events leading to Alzheimer's disease (AD) pathology. Particularly familial AD mutations linked to Presenilins result in exaggerated agonist-evoked calcium release from endoplasmic reticulum (ER). Here we r...

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Bibliografische gegevens
Hoofdauteurs: Honarnejad, Kamran, Daschner, Alexander, Giese, Armin, Zall, Andrea, Schmidt, Boris, Szybinska, Aleksandra, Kuznicki, Jacek, Herms, Jochen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2013
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829862/
https://ncbi.nlm.nih.gov/pubmed/24260442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080645
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