Development and Implementation of a High-Throughput Compound Screening Assay for Targeting Disrupted ER Calcium Homeostasis in Alzheimer's Disease

Disrupted intracellular calcium homeostasis is believed to occur early in the cascade of events leading to Alzheimer's disease (AD) pathology. Particularly familial AD mutations linked to Presenilins result in exaggerated agonist-evoked calcium release from endoplasmic reticulum (ER). Here we r...

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Main Authors: Honarnejad, Kamran, Daschner, Alexander, Giese, Armin, Zall, Andrea, Schmidt, Boris, Szybinska, Aleksandra, Kuznicki, Jacek, Herms, Jochen
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829862/
https://ncbi.nlm.nih.gov/pubmed/24260442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080645
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