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STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death
STING gain-of-function mutations cause lung disease and T cell cytopenia through unknown mechanisms. Here, we found that these mutants induce chronic activation of ER stress and unfolded protein response (UPR), leading to T cell death by apoptosis in the Sting(N153S/+) mouse and in human T cells. Me...
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| Publicado no: | J Exp Med |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6446864/ https://ncbi.nlm.nih.gov/pubmed/30886058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20182192 |
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