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Interferon-independent activities of mammalian STING mediate antiviral response and tumor immune evasion
Type I interferon (IFN) response is commonly recognized as the main signaling activity of STING. Here, we generated the Sting1(S365A/S365A) mutant mouse that precisely ablated IFN-dependent while preserving IFN-independent activities of Sting. Surprisingly, Sting(S365A/S365A) mice protected against...
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| Publicado no: | Immunity |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7365768/ https://ncbi.nlm.nih.gov/pubmed/32640258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2020.06.009 |
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