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STING activation by translocation from the ER is associated with infection and autoinflammatory disease
STING is an ER-associated membrane protein that is critical for innate-immune sensing of pathogens. STING-mediated activation of the IFN-I pathway through the TBK1/IRF3 signaling axis involves both cyclic-dinucleotide binding, and its translocation from the ER to vesicles. However, how these events...
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| Publicado no: | Cell Host Microbe |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4537353/ https://ncbi.nlm.nih.gov/pubmed/26235147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.07.001 |
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