Development and Implementation of a High-Throughput Compound Screening Assay for Targeting Disrupted ER Calcium Homeostasis in Alzheimer's Disease

Disrupted intracellular calcium homeostasis is believed to occur early in the cascade of events leading to Alzheimer's disease (AD) pathology. Particularly familial AD mutations linked to Presenilins result in exaggerated agonist-evoked calcium release from endoplasmic reticulum (ER). Here we r...

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Detalhes bibliográficos
Main Authors: Honarnejad, Kamran, Daschner, Alexander, Giese, Armin, Zall, Andrea, Schmidt, Boris, Szybinska, Aleksandra, Kuznicki, Jacek, Herms, Jochen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829862/
https://ncbi.nlm.nih.gov/pubmed/24260442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080645
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