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Novel Role for p21-activated Kinase 2 in Thrombin-induced Monocyte Migration
To understand the role of thrombin in inflammation, we tested its effects on migration of THP-1 cells, a human monocytic cell line. Thrombin induced THP-1 cell migration in a dose-dependent manner. Thrombin induced tyrosine phosphorylation of Pyk2, Gab1, and p115 RhoGEF, leading to Rac1- and RhoA-de...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3829397/ https://ncbi.nlm.nih.gov/pubmed/24025335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.463414 |
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