Novel Role for p21-activated Kinase 2 in Thrombin-induced Monocyte Migration

To understand the role of thrombin in inflammation, we tested its effects on migration of THP-1 cells, a human monocytic cell line. Thrombin induced THP-1 cell migration in a dose-dependent manner. Thrombin induced tyrosine phosphorylation of Pyk2, Gab1, and p115 RhoGEF, leading to Rac1- and RhoA-de...

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Detaylı Bibliyografya
Asıl Yazarlar: Gadepalli, Ravisekhar, Kotla, Sivareddy, Heckle, Mark R., Verma, Shailendra K., Singh, Nikhlesh K., Rao, Gadiparthi N.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2013
Konular:
Signal Transduction
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829397/
https://ncbi.nlm.nih.gov/pubmed/24025335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.463414
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