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Computational Protein Design Quantifies Structural Constraints on Amino Acid Covariation

Amino acid covariation, where the identities of amino acids at different sequence positions are correlated, is a hallmark of naturally occurring proteins. This covariation can arise from multiple factors, including selective pressures for maintaining protein structure, requirements imposed by a spec...

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Bibliografiset tiedot
Päätekijät: Ollikainen, Noah, Kortemme, Tanja
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2013
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828131/
https://ncbi.nlm.nih.gov/pubmed/24244128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003313
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