ITE, A Novel Endogenous Nontoxic Aryl Hydrocarbon Receptor Ligand, Efficiently Suppresses EAU and T-Cell–Mediated Immunity

PURPOSE. Ligands for aryl hydrocarbon receptor (AHR), such as dioxins, are highly toxic. One such ligand, TCDD, was found to exert potent immunosuppressive capacities in mice developing pathogenic autoimmune processes, including EAU, but its toxicity makes it unusable for humans. A recently identifi...

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Main Authors: Nugent, Lindsey F., Shi, Guangpu, Vistica, Barbara P., Ogbeifun, Osato, Hinshaw, Samuel J. H., Gery, Igal
Formato: Artigo
Idioma:Inglês
Publicado: The Association for Research in Vision and Ophthalmology 2013
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828045/
https://ncbi.nlm.nih.gov/pubmed/24150760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.12-11479
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