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RB1 Status in Triple Negative Breast Cancer Cells Dictates Response to Radiation Treatment and Selective Therapeutic Drugs

Triple negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for which only chemotherapy and radiation therapy are currently available. The retinoblastoma (RB1) tumor suppressor is frequently lost in human TNBC. Knockdown of RB1 in luminal BC cells was shown to affect response t...

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Detalhes bibliográficos
Main Authors: Robinson, Tyler J. W., Liu, Jeff C., Vizeacoumar, Frederick, Sun, Thomas, Maclean, Neil, Egan, Sean E., Schimmer, Aaron D., Datti, Alessandro, Zacksenhaus, Eldad
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3827056/
https://ncbi.nlm.nih.gov/pubmed/24265703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078641
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