High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: Interaction with IQ motif-containing factors

Triple-negative breast cancer (TNBC) represents an aggressive subtype, for which radiation and chemotherapy are the only options. Here we describe the identification of disulfiram, an FDA-approved drug used to treat alcoholism, as well as the related compound thiram, as the most potent growth inhibi...

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Detalhes bibliográficos
Main Authors: Robinson, Tyler JW, Pai, Melody, Liu, Jeff C, Vizeacoumar, Frederick, Sun, Thomas, Egan, Sean E, Datti, Alessandro, Huang, Jing, Zacksenhaus, Eldad
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3875676/
https://ncbi.nlm.nih.gov/pubmed/23974104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.26063
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