RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation

Triple-negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for which no specific treatment is currently available. Although the retinoblastoma tumor-suppressor gene (RB1) is frequently lost together with TP53 in TNBC, it is not directly targetable. There is thus great interest...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Jones, Robert A., Robinson, Tyler J., Liu, Jeff C., Shrestha, Mariusz, Voisin, Veronique, Ju, YoungJun, Chung, Philip E.D., Pellecchia, Giovanna, Fell, Victoria L., Bae, SooIn, Muthuswamy, Lakshmi, Datti, Alessandro, Egan, Sean E., Jiang, Zhe, Leone, Gustavo, Bader, Gary D., Schimmer, Aaron, Zacksenhaus, Eldad
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096803/
https://ncbi.nlm.nih.gov/pubmed/27571409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81568
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