RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation

Triple-negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for which no specific treatment is currently available. Although the retinoblastoma tumor-suppressor gene (RB1) is frequently lost together with TP53 in TNBC, it is not directly targetable. There is thus great interest...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Jones, Robert A., Robinson, Tyler J., Liu, Jeff C., Shrestha, Mariusz, Voisin, Veronique, Ju, YoungJun, Chung, Philip E.D., Pellecchia, Giovanna, Fell, Victoria L., Bae, SooIn, Muthuswamy, Lakshmi, Datti, Alessandro, Egan, Sean E., Jiang, Zhe, Leone, Gustavo, Bader, Gary D., Schimmer, Aaron, Zacksenhaus, Eldad
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096803/
https://ncbi.nlm.nih.gov/pubmed/27571409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81568
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