microRNA-143/145 loss induces Ras signaling to promote aggressive Pten-deficient basal-like breast cancer

The tumor suppressor PTEN is frequently inactivated in breast and other cancers; yet, germ-line mutations in this gene induce nonmalignant hamartomas, indicating dependency on additional cooperating events. Here we show that most tumors derived from conditional deletion of mouse pten in mammary epit...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Wang, Sharon, Liu, Jeff C., Ju, YoungJun, Pellecchia, Giovanna, Voisin, Veronique, Wang, Dong-Yu, Leha l, Rajwinder, Ben-David, Yaacov, Bader, Gary D., Zacksenhaus, Eldad
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543917/
https://ncbi.nlm.nih.gov/pubmed/28768903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93313
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados