microRNA-143/145 loss induces Ras signaling to promote aggressive Pten-deficient basal-like breast cancer

The tumor suppressor PTEN is frequently inactivated in breast and other cancers; yet, germ-line mutations in this gene induce nonmalignant hamartomas, indicating dependency on additional cooperating events. Here we show that most tumors derived from conditional deletion of mouse pten in mammary epit...

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Publicat a:JCI Insight
Autors principals: Wang, Sharon, Liu, Jeff C., Ju, YoungJun, Pellecchia, Giovanna, Voisin, Veronique, Wang, Dong-Yu, Leha l, Rajwinder, Ben-David, Yaacov, Bader, Gary D., Zacksenhaus, Eldad
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543917/
https://ncbi.nlm.nih.gov/pubmed/28768903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93313
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