Psychosine, the cytotoxic sphingolipid that accumulates in globoid cell leukodystrophy, alters membrane architecture

Globoid cell leukodystrophy (GLD) is a neurological disease caused by deficiency of the lysosomal enzyme galactosylceramidase (GALC). In the absence of GALC, the cytotoxic glycosphingolipid, psychosine (psy), accumulates in the nervous system. Psychosine accumulation preferentially affects oligodend...

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Detalhes bibliográficos
Main Authors: Hawkins-Salsbury, Jacqueline A., Parameswar, Archana R., Jiang, Xuntian, Schlesinger, Paul H., Bongarzone, Ernesto, Ory, Daniel S., Demchenko, Alexei V., Sands, Mark S.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826678/
https://ncbi.nlm.nih.gov/pubmed/24006512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M039610
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