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MMP-3 Mediates Psychosine-Induced Globoid Cell Formation: Implications for Leukodystrophy Pathology

Globoid cell leukodystrophy (GLD) or Krabbe disease, is a fatal demyelinating disease attributed to mutations in the galactocerebrosidase (GALC) gene. Loss of function mutations in GALC result in accumulation of the glycolipid intermediate, galactosylsphingosine (psychosine). Due to the cytotoxicity...

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Detalhes bibliográficos
Main Authors: Ijichi, Kumiko, Brown, Graham D., Moore, Craig S., Lee, Jean-Pyo, Winokur, Paige N., Pagarigan, Roberto, Snyder, Evan Y., Bongarzone, Ernesto R., Crocker, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3804069/
https://ncbi.nlm.nih.gov/pubmed/23404611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.22471
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