Human Serotonin 5-HT(2C) G Protein-Coupled Receptor Homology Model from the β(2) Adrenoceptor Structure: Ligand Docking and Mutagenesis Studies

Activation of the serotonin (5-hydroxytryptamine, 5-HT) 5HT(2C) G protein-coupled receptor (GPCR) is proposed as novel pharmacotherapy for obesity and neuropsychiatric disorders. In contrast, activation of the 5-HT(2A) and 5-HT(2B) GPCRs is associated with untoward hallucinogenic and cardiopulmonary...

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Hlavní autoři: RDOVA-SINTJAGO, TANIA CÓ, VILLA, NANCY, CANAL, CLINTON, BOOTH, RAYMOND
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826658/
https://ncbi.nlm.nih.gov/pubmed/24244046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/qua.23231
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