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Design of e-pharmacophore models using compound fragments for the trans-sialidase of Trypanosoma cruzi: screening for novel inhibitor scaffolds
Chagas’ is a fatal disease that affects millions of people worldwide. The lack of safe and effective treatments for Chagas’ highlights the need for the discovery of new drugs to fight the disease. Trypanosoma cruzi, the parasitic cause of Chagas’ disease, synthesizes a trans-sialidase (TcTS) enzyme...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3824395/ https://ncbi.nlm.nih.gov/pubmed/24012872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmgm.2013.08.009 |
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