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Proton transfer facilitated by ligand binding. An energetic analysis of the Catalytic Mechanism of Trypanosoma cruzi trans-Sialidase
Trans-sialidase is a crucial enzyme for the infection of Trypanosoma cruzi, the protozoa responsible for Chagas’ disease in humans. This enzyme catalyzes the transfer of sialic acids from mammalian host cells to parasitic cell surfaces in order to mask the infection from the host’s immune system. It...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3033446/ https://ncbi.nlm.nih.gov/pubmed/21162542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101648z |
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