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Proton transfer facilitated by ligand binding. An energetic analysis of the Catalytic Mechanism of Trypanosoma cruzi trans-Sialidase

Trans-sialidase is a crucial enzyme for the infection of Trypanosoma cruzi, the protozoa responsible for Chagas’ disease in humans. This enzyme catalyzes the transfer of sialic acids from mammalian host cells to parasitic cell surfaces in order to mask the infection from the host’s immune system. It...

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Bibliografski detalji
Glavni autori: Pierdominici-Sottile, Gustavo, Roitberg, Adrian E.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033446/
https://ncbi.nlm.nih.gov/pubmed/21162542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101648z
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