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Design of e-pharmacophore models using compound fragments for the trans-sialidase of Trypanosoma cruzi: screening for novel inhibitor scaffolds

Chagas’ is a fatal disease that affects millions of people worldwide. The lack of safe and effective treatments for Chagas’ highlights the need for the discovery of new drugs to fight the disease. Trypanosoma cruzi, the parasitic cause of Chagas’ disease, synthesizes a trans-sialidase (TcTS) enzyme...

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Sonraí Bibleagrafaíochta
Main Authors: Miller, Bill R., Roitberg, Adrian E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824395/
https://ncbi.nlm.nih.gov/pubmed/24012872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmgm.2013.08.009
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