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Modulation of Catalytic Function by Differential Plasticity of the Active Site: Case Study of Trypanosoma cruzi trans-Sialidase and Trypanosoma rangeli Sialidase
Trans-sialidase is an essential enzyme for Trypanosoma cruzi, the causative agent of Chagas’ disease, to escape from the host immune system and to invade the host cells. Therefore, Trypanosoma cruzi trans-sialidase (TcTS) presents a potential and appealing therapeutic target for this lethal disease....
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2713503/ https://ncbi.nlm.nih.gov/pubmed/19216574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802230y |
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