DYSAPOPTOSIS OF OSTEOBLASTS AND OSTEOCYTES INCREASES CANCELLOUS BONE FORMATION BUT EXAGGERATES BONE POROSITY WITH AGE

Skeletal aging is accompanied by decreased cancellous bone mass and increased formation of pores within cortical bone. The latter accounts for a large portion of the increase in non-vertebral fractures after age 65 in humans. We selectively deleted Bak and Bax, two genes essential for apoptosis, in...

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Auteurs principaux: Jilka, Robert L., O’Brien, Charles A., Roberson, Paula K., Bonewald, Lynda F., Weinstein, Robert S., Manolagas, Stavros C.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823639/
https://ncbi.nlm.nih.gov/pubmed/23761243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2007
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