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Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases
Gain-of-function mutations in the genes encoding Janus kinases have been discovered in various haematologic diseases. Jaks are composed of a FERM domain, an SH2 domain, a pseudokinase domain and a kinase domain, and a complex interplay of the Jak domains is involved in regulation of catalytic activi...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Blackwell Publishing Ltd
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3823453/ https://ncbi.nlm.nih.gov/pubmed/20132407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2010.01018.x |
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