JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms

Por Gäbler, Karoline, Behrmann, Iris, Haan, Claude
Publicado em 2013

Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases

Por Haan, Claude, Behrmann, Iris, Haan, Serge
Publicado em 2010

Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation.

Por Haan, Claude, Heinrich, Peter C, Behrmann, Iris
Publicado em 2002

ROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells

Por Cesi, Giulia, Walbrecq, Geoffroy, Zimmer, Andreas, Kreis, Stephanie, Haan, Claude
Publicado no Mol Cancer (2017)

Phosphorylation of the pyruvate dehydrogenase complex precedes HIF-1-mediated effects and pyruvate dehydrogenase kinase 1 upregulation during the first hours of hypoxic treatment i...

Por Zimmer, Andreas David, Walbrecq, Geoffroy, Kozar, Ines, Behrmann, Iris, Haan, Claude
Publicado no Hypoxia (Auckl) (2016)

Oncostatin M induces RIG‐I and MDA5 expression and enhances the double‐stranded RNA response in fibroblasts

Por Hergovits, Sabine, Mais, Christine, Haan, Claude, Costa‐Pereira, Ana P., Hermanns, Heike M.
Publicado no J Cell Mol Med (2017)

Recombinant Interleukin-24 Lacks Apoptosis-Inducing Properties in Melanoma Cells

Por Kreis, Stephanie, Philippidou, Demetra, Margue, Christiane, Rolvering, Catherine, Haan, Claude, Dumoutier, Laure, Renauld, Jean-Christophe, Behrmann, Iris
Publicado em 2007

The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells

Por Battello, Nadia, Zimmer, Andreas David, Goebel, Carole, Dong, Xiangyi, Behrmann, Iris, Haan, Claude, Hiller, Karsten, Wegner, Andre
Publicado no Cancer Metab (2016)

JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells

Por Wolf, Alexandra, Eulenfeld, René, Gäbler, Karoline, Rolvering, Catherine, Haan, Serge, Behrmann, Iris, Denecke, Bernd, Haan, Claude, Schaper, Fred
Publicado em 2013

Cooperative effects of Janus and Aurora kinase inhibition by CEP701 in cells expressing Jak2V617F

Por Gäbler, Karoline, Rolvering, Catherine, Kaczor, Jakub, Eulenfeld, René, Méndez, Sergio Álvarez, Berchem, Guy, Palissot, Valérie, Behrmann, Iris, Haan, Claude
Publicado em 2013

The oncogenic FIP1L1-PDGFRα fusion protein displays skewed signaling properties compared to its wild-type PDGFRα counterpart

Por Haan, Serge, Bahlawane, Christelle, Wang, Jiali, Nazarov, Petr V, Muller, Arnaud, Eulenfeld, René, Haan, Claude, Rolvering, Catherine, Vallar, Laurent, Satagopam, Venkata P, Sauter, Thomas, Wiesinger, Monique Yvonne
Publicado no JAKSTAT (2015)

SIAH2 antagonizes TYK2-STAT3 signaling in lung carcinoma cells

Por Müller, Sylvia, Chen, Yuan, Ginter, Torsten, Schäfer, Claudia, Buchwald, Marc, Schmitz, Lienhard M., Klitzsch, Jana, Schütz, Alexander, Haitel, Andrea, Schmid, Katharina, Moriggl, Richard, Kenner, Lukas, Friedrich, Karlheinz, Haan, Claude, Petersen, Iver, Heinzel, Thorsten, Krämer, Oliver H.
Publicado em 2014