Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation.

We analysed the interaction of gp130, the common signal-transducing receptor chain of interleukin (IL)-6 type cytokines, with Jak1, the Janus family kinase which is crucial for signal transduction of this group of cytokines. With a truncated chimaeric IL-5Rbeta-gp130 receptor expressed in COS-7 cell...

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Hlavní autoři: Haan, Claude, Heinrich, Peter C, Behrmann, Iris
Médium: Artigo
Jazyk:Inglês
Vydáno: 2002
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222284/
https://ncbi.nlm.nih.gov/pubmed/11742534
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